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Selection of three miRNA signatures with prognostic value in non-M3 acute myeloid leukemia.


ABSTRACT: BACKGROUND:MiRNAs that are potential biomarkers for predicting prognosis for acute myeloid leukemia (AML) have been identified. However, comprehensive analyses investigating the association between miRNA expression profiles and AML survival remain relatively deficient. METHOD:In the present study, we performed multivariate Cox's analysis and principal component analysis (PCA) using data from The Cancer Genome Atlas (TCGA) to identify potential molecular signatures for predicting non-M3 AML prognosis. RESULT:We found that patients who were still living were significantly younger at diagnosis than those who had died (P?=?0.001). In addition, there was a marked difference in living status among different risk category groups (P?=?0.022). A multivariate Cox model suggested that three miRNAs were potential biomarkers of non-M3 AML prognosis, including miR-181a-2, miR-25 and miR-362. Subsequently, PCA analyses were conducted to comprehensively represent the expression levels of these three miRNAs in each patient with a PCA value. According to the log-rank test, AML outcome for patients with lower PCA values was significantly different from those with higher PCA values (P?

SUBMITTER: Xue Y 

PROVIDER: S-EPMC6483142 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Selection of three miRNA signatures with prognostic value in non-M3 acute myeloid leukemia.

Xue Yao Y   Ge Yuqiu Y   Kang Meiyun M   Wu Cong C   Wang Yaping Y   Rong Liucheng L   Fang Yongjun Y  

BMC cancer 20190130 1


<h4>Background</h4>MiRNAs that are potential biomarkers for predicting prognosis for acute myeloid leukemia (AML) have been identified. However, comprehensive analyses investigating the association between miRNA expression profiles and AML survival remain relatively deficient.<h4>Method</h4>In the present study, we performed multivariate Cox's analysis and principal component analysis (PCA) using data from The Cancer Genome Atlas (TCGA) to identify potential molecular signatures for predicting n  ...[more]

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