Dataset Information

The impact of infectious disease consultation in candidemia in a tertiary care hospital in Japan over 12 years.

ABSTRACT:

Background

Candidemia is one of the major causes of morbidity and mortality as a hospital acquired infection. Infectious diseases consultation (IDC) might be beneficial to improve candidemia outcomes; however, only limited data from short periods of time are available thus far.

Methods

An observational study of all candidemia patients at a large tertiary care hospital between 2002 and 2013 was conducted. A candidemia episode was defined as ? 1 positive result for Candida spp. in blood culture. Patients who died or transferred to another hospital within two days after their first positive blood culture were excluded. Independent risk factors for 30-day mortality were determined.

Results

Among 275 patients with 283 episodes of candidemia, 194 (68.6%) were male, and the mean age was 70.0 ± 15.8 years. Central line-associated bloodstream infections, peripheral line-associated bloodstream infections, intra-abdominal infection, and unknown source comprised 220 (77.7%), 35 (12.4%), 13 (4.7%), and 15 (5.3%) episodes, respectively. A total of 126 patients (44.5%) received IDC. Factors independently associated with 30-day mortality in patients with candidemia were urinary catheters use (adjusted hazard ratio [HR] = 2.94; 95% confidence interval [CI] = 1.48-5.87; P = 0.002) and severe sepsis/septic shock (adjusted HR = 2.10; 95% CI = 1.20-3.65; P = 0.009). IDC was associated with a 46% reduction in 30-day mortality (adjusted HR = 0.54; 95% CI = 0.32-0.90; P = 0.017).

Conclusion

IDC was independently associated with a reduction in 30-day mortality. Only 44.5% of patients with candidemia in this cohort received IDC. Routine IDC should be actively considered for patients with candidemia.

SUBMITTER: Ishikane M

PROVIDER: S-EPMC6483235 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

The impact of infectious disease consultation in candidemia in a tertiary care hospital in Japan over 12 years.

Ishikane Masahiro M Hayakawa Kayoko K Kutsuna Satoshi S Takeshita Nozomi N Ohmagari Norio N

PloS one 20190425 4

<h4>Background</h4>Candidemia is one of the major causes of morbidity and mortality as a hospital acquired infection. Infectious diseases consultation (IDC) might be beneficial to improve candidemia outcomes; however, only limited data from short periods of time are available thus far.<h4>Methods</h4>An observational study of all candidemia patients at a large tertiary care hospital between 2002 and 2013 was conducted. A candidemia episode was defined as ≥ 1 positive result for Candida spp. in b ...[more]

PMID: 31022251

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Dataset Information

The impact of infectious disease consultation in candidemia in a tertiary care hospital in Japan over 12 years.

Background

Methods

Results

Conclusion

Publications

The impact of infectious disease consultation in candidemia in a tertiary care hospital in Japan over 12 years.

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