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HMGB proteins are required for sexual development in Aspergillus nidulans.

ABSTRACT: Aspergillus nidulans has three high mobility group box (HMGB) proteins, HmbA, HmbB and HmbC that are chromatin-associated architectural proteins involved in DNA-related functions. By creating and studying deletion strains in both veA+ and veA1 background, we have characterized the role of HmbA, HmbB and HmbC in sexual development. Expression of the mating-type MAT1-1 and MAT1-2 coding genes were found to be extremely down-regulated in all three mutants on day 4 of sexual development, which results in deficient ascospore production and/or ascospore viability in the mutants. In addition, we found that HmbA and HmbB play also a role in sensing of and response to environmental signals, while HmbC functionally interacts with VeA, a key regulator of the coordination of asexual and sexual development, as well as of secondary metabolism.

SUBMITTER: Bokor E

PROVIDER: S-EPMC6483251 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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HMGB proteins are required for sexual development in Aspergillus nidulans.

Bokor Eszter E Ámon Judit J Keisham Kabichandra K Karácsony Zoltán Z Vágvölgyi Csaba C Hamari Zsuzsanna Z

PloS one 20190425 4

Aspergillus nidulans has three high mobility group box (HMGB) proteins, HmbA, HmbB and HmbC that are chromatin-associated architectural proteins involved in DNA-related functions. By creating and studying deletion strains in both veA+ and veA1 background, we have characterized the role of HmbA, HmbB and HmbC in sexual development. Expression of the mating-type MAT1-1 and MAT1-2 coding genes were found to be extremely down-regulated in all three mutants on day 4 of sexual development, which resul ...[more]

PMID: 31022275

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