Ontology highlight
ABSTRACT:
SUBMITTER: Nicholson MD
PROVIDER: S-EPMC6483269 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Nicholson Michael D MD Antal Tibor T
PLoS computational biology 20190415 4
Investigating the emergence of a particular cell type is a recurring theme in models of growing cellular populations. The evolution of resistance to therapy is a classic example. Common questions are: when does the cell type first occur, and via which sequence of steps is it most likely to emerge? For growing populations, these questions can be formulated in a general framework of branching processes spreading through a graph from a root to a target vertex. Cells have a particular fitness value ...[more]