Dataset Information

Changes in body composition and weight during the menopause transition.

ABSTRACT:

Background

The relation between the menopause transition (MT) and changes in body composition or weight remains uncertain. We hypothesized that, independent of chronological aging, the MT would have a detrimental influence on body composition.

Methods

Participants were from the longitudinal Study of Women's Health Across the Nation (SWAN) cohort. We assessed body composition by dual energy x-ray absorptiometry. Multivariable mixed effects regressions fitted piece-wise linear models to repeated measures of outcomes as a function of time before or after the final menstrual period (FMP). Covariates were age at FMP, race, study site, and hormone therapy.

Results

Fat and lean mass increased prior to the MT. At the start of the MT, rate of fat gain doubled, and lean mass declined; gains and losses continued until 2 years after the FMP. After that, the trajectories of fat and lean mass decelerated to zero slope. Weight climbed linearly during premenopause without acceleration at the MT. Its trajectory became flat after the MT.

Conclusion

Accelerated gains in fat mass and losses of lean mass are MT-related phenomena. The rate of increase in the sum of fat mass and lean mass does not differ between premenopause and the MT; thus, there is no discernable change in rate of weight gain at the start of the MT.

Funding

NIH, Department of Health and Human Services (DHHS), through the National Institute on Aging, National Institute of Nursing Research, and NIH Office of Research on Women's Health (U01NR004061, U01AG012505, U01AG012535, U01AG012531, U01AG012539, U01AG012546, U01AG012553, U01AG012554, and U01AG012495).

SUBMITTER: Greendale GA

PROVIDER: S-EPMC6483504 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Changes in body composition and weight during the menopause transition.

Greendale Gail A GA Sternfeld Barbara B Huang MeiHua M Han Weijuan W Karvonen-Gutierrez Carrie C Ruppert Kristine K Cauley Jane A JA Finkelstein Joel S JS Jiang Sheng-Fang SF Karlamangla Arun S AS

JCI insight 20190307 5

<h4>Background</h4>The relation between the menopause transition (MT) and changes in body composition or weight remains uncertain. We hypothesized that, independent of chronological aging, the MT would have a detrimental influence on body composition.<h4>Methods</h4>Participants were from the longitudinal Study of Women's Health Across the Nation (SWAN) cohort. We assessed body composition by dual energy x-ray absorptiometry. Multivariable mixed effects regressions fitted piece-wise linear model ...[more]

PMID: 30843880

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Dataset Information

Changes in body composition and weight during the menopause transition.

Background

Methods

Results

Conclusion

Funding

Publications

Changes in body composition and weight during the menopause transition.

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