Enterococcus faecium secreted antigen A generates muropeptides to enhance host immunity and limit bacterial pathogenesis.
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ABSTRACT:
SUBMITTER: Kim B
PROVIDER: S-EPMC6483599 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
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<i>Enterococcus faecium</i> secreted antigen A generates muropeptides to enhance host immunity and limit bacterial pathogenesis.
Kim Byungchul B Wang Yen-Chih YC Hespen Charles W CW Espinosa Juliel J Salje Jeanne J Rangan Kavita J KJ Oren Deena A DA Kang Jin Young JY Pedicord Virginia A VA Hang Howard C HC
eLife 20190410
We discovered that <i>Enterococcus faecium</i> (<i>E. faecium</i>), a ubiquitous commensal bacterium, and its secreted peptidoglycan hydrolase (SagA) were sufficient to enhance intestinal barrier function and pathogen tolerance, but the precise biochemical mechanism was unknown. Here we show <i>E. faecium</i> has unique peptidoglycan composition and remodeling activity through SagA, which generates smaller muropeptides that more effectively activates nucleotide-binding oligomerization domain-con ...[more]
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