Ontology highlight
ABSTRACT:
SUBMITTER: Abe JI
PROVIDER: S-EPMC6483653 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Abe Jun-Ichi JI Ko Kyung Ae KA Kotla Sivareddy S Wang Yin Y Paez-Mayorga Jesus J Shin Ik Jae IJ Imanishi Masaki M Vu Hang Thi HT Tao Yunting Y Leiva-Juarez Miguel M MM Thomas Tamlyn N TN Medina Jan L JL Won Jong Hak JH Fujii Yuka Y Giancursio Carolyn J CJ McBeath Elena E Shin Ji-Hyun JH Guzman Liliana L Abe Rei J RJ Taunton Jack J Mochizuki Naoki N Faubion William W Cooke John P JP Fujiwara Keigi K Evans Scott E SE Le Nhat-Tu NT
JCI insight 20190404 7
The possible association between the membrane-associated guanylate kinase with inverted domain structure-1 (MAGI1) and inflammation has been suggested, but the molecular mechanisms underlying this link, especially during atherogenesis, remain unclear. In endothelial cells (ECs) exposed to disturbed flow (d-flow), p90 ribosomal S6 kinase (p90RSK) bound to MAGI1, causing MAGI1-S741 phosphorylation and sentrin/SUMO-specific protease 2 T368 phosphorylation-mediated MAGI1-K931 deSUMOylation. MAGI1-S7 ...[more]