Ontology highlight
ABSTRACT:
SUBMITTER: Tuladhar R
PROVIDER: S-EPMC6484125 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Tuladhar Rubina R Yarravarapu Nageswari N Ma Yuyong Y Zhang Chengwei C Herbert Jeremiah J Kim James J Chen Chuo C Lum Lawrence L
The Journal of biological chemistry 20190208 16
The maintenance of adult animal tissues depends upon highly conserved intercellular signaling molecules that include the secreted WNT proteins. Although it is generally accepted that lipidation of WNTs by the acyltransferase Porcupine (PORCN) and their subsequent recognition by the Wntless (WLS) protein is essential for their cellular secretion, the molecular understanding of this process remains limited. Using structurally diverse fatty acyl donor analogs and mouse embryonic fibroblasts express ...[more]