Ontology highlight
ABSTRACT:
SUBMITTER: Maslon MM
PROVIDER: S-EPMC6484407 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
The EMBO journal 20190415 9
The rate of RNA polymerase II (RNAPII) elongation has an important role in the control of alternative splicing (AS); however, the <i>in vivo</i> consequences of an altered elongation rate are unknown. Here, we generated mouse embryonic stem cells (ESCs) knocked in for a slow elongating form of RNAPII We show that a reduced transcriptional elongation rate results in early embryonic lethality in mice. Focusing on neuronal differentiation as a model, we observed that slow elongation impairs develop ...[more]