Ontology highlight
ABSTRACT:
SUBMITTER: Hald OH
PROVIDER: S-EPMC6484764 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Hald Øyvind H ØH Olsen Lotte L Gallo-Oller Gabriel G Elfman Lotta Helena Maria LHM Løkke Cecilie C Kogner Per P Sveinbjörnsson Baldur B Flægstad Trond T Johnsen John Inge JI Einvik Christer C
Oncogene 20181212 15
Abnormal increases in nucleolar size and number caused by dysregulation of ribosome biogenesis has emerged as a hallmark in the majority of spontaneous cancers. The observed ribosome hyperactivity can be directly induced by the MYC transcription factors controlling the expression of RNA and protein components of the ribosome. Neuroblastoma, a highly malignant childhood tumor of the sympathetic nervous system, is frequently characterized by MYCN gene amplification and high expression of MYCN and ...[more]