Ontology highlight
ABSTRACT:
SUBMITTER: Roy CJ
PROVIDER: S-EPMC6485354 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Roy Chad J CJ Ehrbar Dylan J DJ Bohorova Natasha N Bohorov Ognian O Kim Do D Pauly Michael M Whaley Kevin K Rong Yinghui Y Torres-Velez Fernando J FJ Vitetta Ellen S ES Didier Peter J PJ Doyle-Meyers Lara L Zeitlin Larry L Mantis Nicholas J NJ
JCI insight 20190110 1
Ricin toxin (RT) ranks at the top of the list of bioweapons of concern to civilian and military personnel alike, due to its high potential for morbidity and mortality after inhalation. In nonhuman primates, aerosolized ricin triggers severe acute respiratory distress characterized by perivascular and alveolar edema, neutrophilic infiltration, and severe necrotizing bronchiolitis and alveolitis. There are currently no approved countermeasures for ricin intoxication. Here, we report the therapeuti ...[more]