In situ architecture, function, and evolution of a contractile injection system.
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ABSTRACT:
SUBMITTER: Bock D
PROVIDER: S-EPMC6485382 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Publications
In situ architecture, function, and evolution of a contractile injection system.
Böck Désirée D Medeiros João M JM Tsao Han-Fei HF Penz Thomas T Weiss Gregor L GL Aistleitner Karin K Horn Matthias M Pilhofer Martin M
Science (New York, N.Y.) 20170801 6352
Contractile injection systems mediate bacterial cell-cell interactions by a bacteriophage tail-like structure. In contrast to extracellular systems, the type 6 secretion system (T6SS) is defined by intracellular localization and attachment to the cytoplasmic membrane. Here we used cryo-focused ion beam milling, electron cryotomography, and functional assays to study a T6SS in <i>Amoebophilus asiaticus</i> The in situ architecture revealed three modules, including a contractile sheath-tube, a bas ...[more]
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