Ontology highlight
ABSTRACT:
SUBMITTER: Sacristan C
PROVIDER: S-EPMC6485389 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Sacristan Carlos C Ahmad Misbha Ud Din MUD Keller Jenny J Fermie Job J Groenewold Vincent V Tromer Eelco E Fish Alexander A Melero Roberto R Carazo José María JM Klumperman Judith J Musacchio Andrea A Perrakis Anastassis A Kops Geert Jpl GJ
Nature cell biology 20180618 7
Faithful chromosome segregation depends on the ability of sister kinetochores to attach to spindle microtubules. The outer layer of kinetochores transiently expands in early mitosis to form a fibrous corona, and compacts following microtubule capture. Here we show that the dynein adaptor Spindly and the RZZ (ROD-Zwilch-ZW10) complex drive kinetochore expansion in a dynein-independent manner. C-terminal farnesylation and MPS1 kinase activity cause conformational changes of Spindly that promote ol ...[more]