Ontology highlight
ABSTRACT:
SUBMITTER: Gebala V
PROVIDER: S-EPMC6485462 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Gebala Véronique V Collins Russell R Geudens Ilse I Phng Li-Kun LK Gerhardt Holger H
Nature cell biology 20160229 4
How vascular tubes build, maintain and adapt continuously perfused lumens to meet local metabolic needs remains poorly understood. Recent studies showed that blood flow itself plays a critical role in the remodelling of vascular networks, and suggested it is also required for the lumenization of new vascular connections. However, it is still unknown how haemodynamic forces contribute to the formation of new vascular lumens during blood vessel morphogenesis. Here we report that blood flow drives ...[more]