Dataset Information

Diurnal change of retinal vessel density and mean ocular perfusion pressure in patients with open-angle glaucoma.

ABSTRACT:

Purpose

To investigate, in primary open-angle glaucoma (POAG) and healthy subjects, the pattern and magnitude of diurnal variation in optical coherence tomography angiography (OCTA) retinal vessel density (RVD).

Design

Prospective, observational cross-sectional study.

Participants

A prospective study was conducted on 20POAG patients and 19 healthy subjects.

Methods

Peripapillary/macular RVD (using swept-source OCTA), intraocular pressure (IOP), and systemic blood pressure (BP) were measured five times a day (8 a.m., 11 a.m., 2 p.m.,5 p.m. and 8 p.m.). The magnitudes and patterns of diurnal changes in RVD, diastolic BP, and mean ocular-perfusion pressure (MOPP) were analyzed and compared between the POAG patients and the healthy subjects.

Main outcome measures

The patterns and magnitudes of diurnal RVD change in OCTA.

Results

Intra-visit repeatability (0.755-0.943) and inter-visit reproducibility (0.843-0.986) for the RVD measurements showed excellent reliability. In the POAG patients, the magnitude of diurnal change in peripapillary RVD (9.71±7.04%) and macular RVD (7.22±4.73%) were significantly greater than that in the healthy group (5.73±3.85%, P = 0.013 and 5.51±3.45%, P = 0.042, respectively). The magnitudes of diurnal variations of IOP and MOPP in the POAG group likewise were greater than those in the healthy group (P = 0.003 and 0.039). As for the patterns of diurnal RVD change, interestingly, at 8 p.m., the macular RVD of the healthy group increased to the highest level (44.12±2.95%) while that of the POAG group decreased to the lowest level (40.41±2.54%).

Conclusions

In POAG eyes, diurnal change of IOP, MOPP and RVD was significantly greater than in the healthy eyes. These findings suggest that diurnal RVD changes might reflect the hemodynamic variation of POAG.

SUBMITTER: Baek SU

PROVIDER: S-EPMC6485647 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Diurnal change of retinal vessel density and mean ocular perfusion pressure in patients with open-angle glaucoma.

Baek Sung Uk SU Kim Young Kook YK Ha Ahnul A Kim Yong Woo YW Lee Jinho J Kim Jin-Soo JS Jeoung Jin Wook JW Park Ki Ho KH

PloS one 20190426 4

<h4>Purpose</h4>To investigate, in primary open-angle glaucoma (POAG) and healthy subjects, the pattern and magnitude of diurnal variation in optical coherence tomography angiography (OCTA) retinal vessel density (RVD).<h4>Design</h4>Prospective, observational cross-sectional study.<h4>Participants</h4>A prospective study was conducted on 20POAG patients and 19 healthy subjects.<h4>Methods</h4>Peripapillary/macular RVD (using swept-source OCTA), intraocular pressure (IOP), and systemic blood pre ...[more]

PMID: 31026291

Similar Datasets

Project description:PURPOSE:To characterize OCT angiography (OCT-A) vessel density of patients with primary open-angle glaucoma (POAG) with unilateral visual field (VF) loss. DESIGN:Cross-sectional study. PARTICIPANTS:A total of 33 patients with POAG with a VF defect in 1 eye (mean VF mean deviation [MD], -3.9±3.1 decibels [dB]) and normal VF in the other eye (mean VF MD, -0.2±0.9 dB) and 33 healthy eyes. METHODS:All subjects underwent OCT-A imaging, spectral-domain (SD)-OCT imaging, and VF testing. OCT-A retinal vascular measurements were summarized as whole image vessel density (wiVD), circumpapillary vessel density (cpVD), and parafoveal vessel density (pfVD). Inter-eye differences in vascular measures, as well as SD OCT retinal nerve fiber layer (RNFL), macular ganglion cell complex (mGCC) thickness, and rim area measurements in glaucoma and healthy eyes were compared. Areas under the receiver operating characteristic curves (AUROCs) were used to evaluate diagnostic accuracy for differentiating between unaffected eyes of patients with POAG and healthy eyes. MAIN OUTCOME MEASURES:Difference in OCT-A vessel density and SD OCT structural parameters between unaffected eyes of patients with POAG with the fellow affected eyes and healthy controls. RESULTS:Mean wiVD in unaffected eyes of patients with POAG (52.0%) was higher than in their fellow affected eyes (48.8%) but lower than in healthy eyes (55.9%; P < 0.001). Mean circumpapillary RNFL (cpRNFL) thickness, mGCC thickness, and rim area measurement in unaffected eyes of patients with POAG (87.5 ?m, 87.7 ?m, and 1.0 mm2) were also higher than those measurements in their fellow eyes (76.5 ?m, 79.5 ?m, and 0.8 mm2; P < 0.001) and lower than in healthy eyes (98.0 ?m, 94.5 ?m, and 1.4 mm2; P < 0.001). The AUROCs for differentiating unaffected eyes of patients with POAG from healthy eyes were highest for wiVD (0.84), followed by mGCC (0.78), cpRNFL (0.77), and pfVD (0.69). CONCLUSIONS:OCT-A measures detect changes in retinal microvasculature before VF damage is detectable in patients with POAG, and these changes may reflect damage to tissues relevant to the pathophysiology of glaucoma. Longitudinal studies are needed to determine whether OCT-A measures can improve the detection or prediction of the onset and progression of glaucoma.

Dataset Information

Diurnal change of retinal vessel density and mean ocular perfusion pressure in patients with open-angle glaucoma.

Purpose

Design

Participants

Methods

Main outcome measures

Results

Conclusions

Publications

Diurnal change of retinal vessel density and mean ocular perfusion pressure in patients with open-angle glaucoma.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure