Bisphosphonates and other bone agents for breast cancer.
Ontology highlight
ABSTRACT:
SUBMITTER: O'Carrigan B
PROVIDER: S-EPMC6485886 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
Bisphosphonates and other bone agents for breast cancer.
O'Carrigan Brent B Wong Matthew Hf MH Willson Melina L ML Stockler Martin R MR Pavlakis Nick N Goodwin Annabel A
The Cochrane database of systematic reviews 20171030
<h4>Background</h4>Bone is the most common site of metastatic disease associated with breast cancer (BC). Bisphosphonates inhibit osteoclast-mediated bone resorption, and novel targeted therapies such as denosumab inhibit other key bone metabolism pathways. We have studied these agents in both early breast cancer and advanced breast cancer settings. This is an update of the review originally published in 2002 and subsequently updated in 2005 and 2012.<h4>Objectives</h4>To assess the effects of b ...[more]
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