Ontology highlight
ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC6486342 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Chen Zhengxin Z Wang Hong-Wei HW Wang Shuai S Fan Ligang L Feng Shuang S Cai Xiaomin X Peng Chenghao C Wu Xiaoting X Lu Jiacheng J Chen Dan D Chen Yuanyuan Y Wu Wenting W Lu Daru D Liu Ning N You Yongping Y Wang Huibo H
The Journal of clinical investigation 20190408 5
The mesenchymal (MES) subtype of glioblastoma (GBM) stem cells (GSCs) represents a subpopulation of cancer cells that are notorious for their highly aggressive nature and resistance to conventional therapy. Aldehyde dehydrogenase 1A3 (ALDH1A3) has been recently suggested as a key determinant for the maintenance of MES features of GSCs. However, the mechanisms underpinning aberrant ALDH1A3 expression remain elusive. Here, we identified ubiquitin-specific protease 9X (USP9X) as a bona fide deubiqu ...[more]