Regional Molecular Mapping of Primate Synapses during Normal Healthy Aging.
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ABSTRACT:
SUBMITTER: Graham LC
PROVIDER: S-EPMC6486486 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Regional Molecular Mapping of Primate Synapses during Normal Healthy Aging.
Graham Laura C LC Naldrett Michael J MJ Kohama Steven G SG Smith Colin C Lamont Douglas J DJ McColl Barry W BW Gillingwater Thomas H TH Skehel Paul P Urbanski Henryk F HF Wishart Thomas M TM
Cell reports 20190401 4
Normal mammalian brain aging is characterized by the selective loss of discrete populations of dendritic spines and synapses, particularly affecting neuroanatomical regions such as the hippocampus. Although previous investigations have quantified this morphologically, the molecular pathways orchestrating preferential synaptic vulnerability remain to be elucidated. Using quantitative proteomics and healthy rhesus macaque and human patient brain regional tissues, we have comprehensively profiled t ...[more]
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