Ontology highlight
ABSTRACT:
SUBMITTER: Kostic M
PROVIDER: S-EPMC6486488 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Cell reports 20190401 4
Neocortex expansion during mammalian evolution has been linked to an increase in proliferation of basal progenitors in the subventricular zone. Here, we explored a potential role of YAP, the major downstream effector of the Hippo pathway, in proliferation of basal progenitors. YAP expression and activity are high in ferret and human basal progenitors, which exhibit high proliferative capacity, but low in mouse basal progenitors, which lack such capacity. Conditional expression of a constitutivel ...[more]