Ontology highlight
ABSTRACT:
SUBMITTER: Choi S
PROVIDER: S-EPMC6486603 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Choi Sunkyung S Sa Moa M Cho Namjoon N Kim Kee K KK Park Su-Hyung SH
Experimental & molecular medicine 20190426 4
Stress granules (SGs) are stalled translation initiation complexes comprising untranslated mRNAs and RNA-binding proteins (RBPs). RBP fox-1 homolog 2 (Rbfox2), a component of SGs, binds to retinoblastoma 1 (RB1) mRNA, which is closely related to cancer progression; however, the role of Rbfox2 in cancer progression remains largely unknown. In this study, we confirmed that Rbfox2, which is present in the nucleus as a splicing regulator, localizes to the cytoplasm of human colon cancer tissues and ...[more]