Ontology highlight
ABSTRACT:
SUBMITTER: Fujikawa T
PROVIDER: S-EPMC6486607 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Experimental & molecular medicine 20190426 4
Phosphoinositide 3-kinase (PI3K) signaling in hypothalamic neurons integrates peripheral metabolic cues, including leptin and insulin, to coordinate systemic glucose and energy homeostasis. PI3K is composed of different subunits, each of which has several unique isoforms. However, the role of the PI3K subunits and isoforms in the ventromedial hypothalamus (VMH), a prominent site for the regulation of glucose and energy homeostasis, is unclear. Here we investigated the role of subunit p110β in st ...[more]