Ontology highlight
ABSTRACT:
SUBMITTER: Noble C
PROVIDER: S-EPMC6486765 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Noble Charleston C Min John J Olejarz Jason J Buchthal Joanna J Chavez Alejandro A Smidler Andrea L AL DeBenedictis Erika A EA Church George M GM Church George M GM Nowak Martin A MA Esvelt Kevin M KM
Proceedings of the National Academy of Sciences of the United States of America 20190402 17
If they are able to spread in wild populations, CRISPR-based gene-drive elements would provide new ways to address ecological problems by altering the traits of wild organisms, but the potential for uncontrolled spread tremendously complicates ethical development and use. Here, we detail a self-exhausting form of CRISPR-based drive system comprising genetic elements arranged in a daisy chain such that each drives the next. "Daisy-drive" systems can locally duplicate any effect achievable by usin ...[more]