Ontology highlight
ABSTRACT:
SUBMITTER: Ardid S
PROVIDER: S-EPMC6486766 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Ardid Salva S Sherfey Jason S JS McCarthy Michelle M MM Hass Joachim J Pittman-Polletta Benjamin R BR Kopell Nancy N
Proceedings of the National Academy of Sciences of the United States of America 20190408 17
Classical accounts of biased competition require an input bias to resolve the competition between neuronal ensembles driving downstream processing. However, flexible and reliable selection of behaviorally relevant ensembles can occur with unbiased stimulation: striatal D1 and D2 spiny projection neurons (SPNs) receive balanced cortical input, yet their activity determines the choice between GO and NO-GO pathways in the basal ganglia. We here present a corticostriatal model identifying three mech ...[more]