Polymeric perfluorocarbon nanoemulsions are ultrasound-activated wireless drug infusion catheters.

ABSTRACT: Catheter-based intra-arterial drug therapies have proven effective for a range of oncologic, neurologic, and cardiovascular applications. However, these procedures are limited by their invasiveness and relatively broad drug spatial distribution. The ideal technique for local pharmacotherapy would be noninvasive and would flexibly deliver a given drug to any region of the body with high spatial and temporal precision. Combining polymeric perfluorocarbon nanoemulsions with existent clinical focused ultrasound systems could in principle meet these needs, but it has not been clear whether these nanoparticles could provide the necessary drug loading, stability, and generalizability across a range of drugs, beyond a few niche applications. Here, we develop polymeric perfluorocarbon nanoemulsions

SUBMITTER: Zhong Q 

PROVIDER: S-EPMC6486876 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature