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Stimulating T Cells Against Cancer With Agonist Immunostimulatory Monoclonal Antibodies.

ABSTRACT: Elimination of cancer cells through antitumor immunity has been a long-sought after goal since Sir F. Macfarlane Burnet postulated the theory of immune surveillance against tumors in the 1950s. Finally, the use of immunotherapeutics against established cancer is becoming a reality in the past 5years. Most notable are the monoclonal antibodies (mAbs) directed against inhibitory T-cell receptors cytotoxic T lymphocyte antigen-4 and programmed death-1. The next generation of mAbs targeting T cells is designed to stimulate costimulatory receptors on T cells. Here we review the recent progress on these immunostimulatory agonist antibodies against the costimulatory receptors CD137, GITR, OX40, and CD27.

SUBMITTER: Han X

PROVIDER: S-EPMC6487201 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Stimulating T Cells Against Cancer With Agonist Immunostimulatory Monoclonal Antibodies.

Han Xue X Vesely Matthew D MD

International review of cell and molecular biology 20180820

Elimination of cancer cells through antitumor immunity has been a long-sought after goal since Sir F. Macfarlane Burnet postulated the theory of immune surveillance against tumors in the 1950s. Finally, the use of immunotherapeutics against established cancer is becoming a reality in the past 5years. Most notable are the monoclonal antibodies (mAbs) directed against inhibitory T-cell receptors cytotoxic T lymphocyte antigen-4 and programmed death-1. The next generation of mAbs targeting T cells ...[more]

PMID: 30635089

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