Ontology highlight
ABSTRACT:
SUBMITTER: Casero RA
PROVIDER: S-EPMC6487480 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Casero Robert A RA Murray Stewart Tracy T Pegg Anthony E AE
Nature reviews. Cancer 20181101 11
Advances in our understanding of the metabolism and molecular functions of polyamines and their alterations in cancer have led to resurgence in the interest of targeting polyamine metabolism as an anticancer strategy. Increasing knowledge of the interplay between polyamine metabolism and other cancer-driving pathways, including the PTEN-PI3K-mTOR complex 1 (mTORC1), WNT signalling and RAS pathways, suggests potential combination therapies that will have considerable clinical promise. Additionall ...[more]