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Discovery of Volatile Biomarkers of Parkinson's Disease from Sebum.

ABSTRACT: Parkinson's disease (PD) is a progressive, neurodegenerative disease that presents with significant motor symptoms, for which there is no diagnostic chemical test. We have serendipitously identified a hyperosmic individual, a "Super Smeller" who can detect PD by odor alone, and our early pilot studies have indicated that the odor was present in the sebum from the skin of PD subjects. Here, we have employed an unbiased approach to investigate the volatile metabolites of sebum samples obtained noninvasively from the upper back of 64 participants in total (21 controls and 43 PD subjects). Our results, validated by an independent cohort (n=31), identified a distinct volatiles-associated signature of PD, including altered levels of perillic aldehyde and eicosane, the smell of which was then described as being highly similar to the scent of PD by our "Super Smeller".

SUBMITTER: Trivedi DK

PROVIDER: S-EPMC6487537 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Discovery of Volatile Biomarkers of Parkinson's Disease from Sebum.

Trivedi Drupad K DK Sinclair Eleanor E Xu Yun Y Sarkar Depanjan D Walton-Doyle Caitlin C Liscio Camilla C Banks Phine P Milne Joy J Silverdale Monty M Kunath Tilo T Goodacre Royston R Barran Perdita P

ACS central science 20190320 4

Parkinson's disease (PD) is a progressive, neurodegenerative disease that presents with significant motor symptoms, for which there is no diagnostic chemical test. We have serendipitously identified a hyperosmic individual, a "Super Smeller" who can detect PD by odor alone, and our early pilot studies have indicated that the odor was present in the sebum from the skin of PD subjects. Here, we have employed an unbiased approach to investigate the volatile metabolites of sebum samples obtained non ...[more]

PMID: 31041379

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2020-12-21 | MTBLS2266 | MetaboLights

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