Ontology highlight
ABSTRACT:
SUBMITTER: Adams RM
PROVIDER: S-EPMC6487650 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Adams Rhys M RM Kinney Justin B JB Walczak Aleksandra M AM Mora Thierry T
Cell systems 20190102 1
Epistasis is the phenomenon by which the effect of a mutation depends on its genetic background. While it is usually defined in terms of organismal fitness, for single proteins, it must reflect physical interactions among residues. Here, we systematically extract the specific contribution pairwise epistasis makes to the physical affinity of antibody-antigen binding relevant to affinity maturation, a process of accelerated Darwinian evolution. We find that, among competing definitions of affinity ...[more]