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Sexual dimorphisms in the transcriptomes of murine salivary glands.


ABSTRACT: Transcriptional profiling identified 933 sexually dimorphic genes out of the 14 371 protein-coding genes expressed in the three major murine salivary glands: parotid, sublingual, and submandibular. Most (89%) sex-specific genes were enriched in a single gland, while only 0.5% of the sexually dimorphic genes were enriched in all glands. The sublingual gland displayed a strong male sex bias (94% of sex-enriched genes), while a sex preference was not obvious in the parotid or submandibular glands. A subset of transcription factor genes was correlated with the expression of gland-specific, sex-enriched genes. Higher expression of Cftr chloride and Scnn1 sodium channels in the male submandibular correlated with greater NaCl reabsorption. In conclusion, adult salivary glands display sex- and gland-specific differences in gene expression that reflect their unique functional properties.

SUBMITTER: Mukaibo T 

PROVIDER: S-EPMC6487692 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Sexual dimorphisms in the transcriptomes of murine salivary glands.

Mukaibo Taro T   Gao Xin X   Yang Ning-Yan NY   Oei Maria S MS   Nakamoto Tetsuji T   Melvin James E JE  

FEBS open bio 20190330 5


Transcriptional profiling identified 933 sexually dimorphic genes out of the 14 371 protein-coding genes expressed in the three major murine salivary glands: parotid, sublingual, and submandibular. Most (89%) sex-specific genes were enriched in a single gland, while only 0.5% of the sexually dimorphic genes were enriched in all glands. The sublingual gland displayed a strong male sex bias (94% of sex-enriched genes), while a sex preference was not obvious in the parotid or submandibular glands.  ...[more]

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