High expression of long non-coding RNA MALAT1 in breast cancer is associated with poor relapse-free survival.

ABSTRACT: PURPOSE:Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been identified as a prognostic marker for the metastasis of early-stage non-small cell lung cancer (NSCLCs). We studied MALAT1 expression in breast cancer in relation to disease features and patient survival. METHODS:Quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) was used to measure MALAT1 expression in tumor samples of 509 breast cancer patients. Hazards ratios (HRs) and 95% confidence intervals (CIs) were calculated to assess the association between MALAT1 expression and breast cancer survival using the Cox proportional hazards regression model, and the analysis was adjusted for age at surgery, tumor grade, disease stage, and hormone receptor status. Meta-analysis of multiple microarray datasets from online databases and our own study was performed to evaluate the association of MALAT1 with breast cancer survival. RESULTS:Patients with low-grade or ER-positive tumors had higher expression of MALAT1 compared to those with high-grade (p?=?0.013) or ER-negative (p?=?0.0002) tumors. Patients with PR-positive tumors also had higher MALAT1 expression than those with PR-negative tumors (p?

SUBMITTER: Wang Z 

PROVIDER: S-EPMC6488226 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature