Ontology highlight
ABSTRACT:
SUBMITTER: Patterson JO
PROVIDER: S-EPMC6488275 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Patterson James O JO Rees Paul P Nurse Paul P
Current biology : CB 20190404 8
How cells correct deviations from a mean cell size at mitosis remains uncertain. Classical cell-size homeostasis models are the sizer, timer, and adder [1]. Sizers postulate that cells divide at some threshold size; timers, that cells grow for a set time; and adders, that cells add a constant volume before division. Here, we show that a size-based probabilistic model of cell-size control at the G2/M transition (P(Div)) can generate realistic cell-size homeostasis in silico. In fission yeast cell ...[more]