Ontology highlight
ABSTRACT:
SUBMITTER: Wang P
PROVIDER: S-EPMC6488304 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20161013 20
Three QS-21-based vaccine adjuvant candidates with a terminal-functionalized side chain incorporated in the west wing trisaccharide have been synthesized. The terminal polar functional group serves to increase the solubility of these analogues in water. Two of the synthetic analogues have been shown to have adjuvant activity comparable to that of GPI-0100. The stand-alone adjuvant activity of the new synthetic analogues again confirmed that it is a feasible way to develop new saponin-based vacci ...[more]