Thalamic and ventricular volumes predict motor response to deep brain stimulation for Parkinson's disease.

ABSTRACT:

Background

Brain atrophy frequently occurs with Parkinson's disease (PD) and relates to increased motor symptoms of PD. The predictive value of neuroimaging-based measures of global and regional brain volume on motor outcomes in deep brain stimulation (DBS) remains unclear but potentially could improve patient selection and targeting.

Objectives

To determine the predictive value of preoperative volumetric MRI measures of cortical and subcortical brain volume on motor outcomes of subthalamic nucleus (STN) DBS in PD.

Methods

Preoperative T1 3D MP-RAGE structural brain MRI images were analyzed for each participant to determine subcortical, ventricular, and cortical volume and thickness. Change in Unified Parkinson's Disease Rating Scale (UPDRS) scores for subsection 3, r

SUBMITTER: Younce JR 

PROVIDER: S-EPMC6488428 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature