Ontology highlight
ABSTRACT:
SUBMITTER: Burgold J
PROVIDER: S-EPMC6488584 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Burgold Johanna J Schulz-Trieglaff Elena Katharina EK Voelkl Kerstin K Gutiérrez-Ángel Sara S Bader Jakob Maximilian JM Hosp Fabian F Mann Matthias M Arzberger Thomas T Klein Rüdiger R Liebscher Sabine S Dudanova Irina I
Scientific reports 20190429 1
Huntington's disease (HD) is a devastating hereditary movement disorder, characterized by degeneration of neurons in the striatum and cortex. Studies in human patients and mouse HD models suggest that disturbances of neuronal function in the neocortex play an important role in disease onset and progression. However, the precise nature and time course of cortical alterations in HD have remained elusive. Here, we use chronic in vivo two-photon calcium imaging to longitudinally monitor the activity ...[more]