Influence of SHH/GLI1 axis on EMT mediated migration and invasion of breast cancer cells.
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ABSTRACT:
SUBMITTER: Riaz SK
PROVIDER: S-EPMC6488587 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Influence of SHH/GLI1 axis on EMT mediated migration and invasion of breast cancer cells.
Riaz Syeda Kiran SK Ke Yuepeng Y Wang Fen F Kayani Mahmood Akhtar MA Malik Muhammad Faraz Arshad MFA
Scientific reports 20190429 1
Sonic Hedgehog signaling is critical for breast morphogenesis and cancer. The present study was conducted to explore the influence of SHH/GLI1 axis on epithelial mesenchymal transition and invasion in breast cancer cells. SHH/GLI1 positive samples demonstrated high expression of Snail and Vimentin with relatively low expression of E-cadherin. Overexpression of Vimentin and Snail in SHH/GLI1 positive patients was also associated with poor overall survival. Interestingly, GANT61 (GLI1 inhibitor) e ...[more]
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