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A tightly-bonded and flexible mesoporous zeolite-cotton hybrid hemostat.

ABSTRACT: Achieving rapid definitive hemostasis is essential to ensure survival of patients with massive bleeding in pre-hospital care. It is however challenging to develop hemostatic agents or dressings that simultaneously deliver a fast, long-lasting and safe treatment of hemorrhage. Here, we integrate meso-/micro-porosity, blood coagulation and stability into a flexible zeolite-cotton hybrid hemostat. We employ an on-site template-free growth route that tightly binds mesoporous single-crystal chabazite zeolite onto the surface of cotton fibers. This hemostatic material maintains high procoagulant activity after water flow treatment. Chabazite particles are firmly anchored onto the cotton surface with?

SUBMITTER: Yu L

PROVIDER: S-EPMC6488602 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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A tightly-bonded and flexible mesoporous zeolite-cotton hybrid hemostat.

Yu Lisha L Shang Xiaoqiang X Chen Hao H Xiao Liping L Zhu Yihan Y Fan Jie J

Nature communications 20190429 1

Achieving rapid definitive hemostasis is essential to ensure survival of patients with massive bleeding in pre-hospital care. It is however challenging to develop hemostatic agents or dressings that simultaneously deliver a fast, long-lasting and safe treatment of hemorrhage. Here, we integrate meso-/micro-porosity, blood coagulation and stability into a flexible zeolite-cotton hybrid hemostat. We employ an on-site template-free growth route that tightly binds mesoporous single-crystal chabazite ...[more]

PMID: 31036816

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