Ontology highlight
ABSTRACT:
SUBMITTER: Jeong S
PROVIDER: S-EPMC6488704 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Jeong SeungJoo S Ko Juyeon J Kim Minji M Park Ki Chul KC Park Eunice Yon June EYJ Kim Jinsung J Baik Youngjoo Y Wie Jinhong J Cho Art E AE Jeon Ju-Hong JH So Insuk I
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20190424 3
The transient receptor potential canonical (TRPC) 5 channel, known as a nonselective cation channel, has a crucial role in calcium influx. TRPC5 has been reported to be activated by muscarinic receptor activation and extracellular pH change and inhibited by the protein kinase C pathway. Recent studies have also suggested that TRPC5 is extracellularly activated by englerin A (EA), but the mechanism remains unclear. The purpose of this study is to identify the EA-interaction sites in TRPC5 and the ...[more]