Metabolic programming of macrophage functions and pathogens control.
Ontology highlight
ABSTRACT:
SUBMITTER: Koo SJ
PROVIDER: S-EPMC6488820 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
Metabolic programming of macrophage functions and pathogens control.
Koo Sue-Jie SJ Garg Nisha J NJ
Redox biology 20190420
Macrophages (Mφ) are central players in mediating proinflammatory and immunomodulatory functions. Unchecked Mφ activities contribute to pathology across many diseases, including those caused by infectious pathogens and metabolic disorders. A fine balance of Mφ responses is crucial, which may be achieved by enforcing appropriate bioenergetics pathways. Metabolism serves as the provider of energy, substrates, and byproducts that support differential Mφ characteristics. The metabolic properties tha ...[more]
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