Regulation of global gene expression in brain by TMP21.
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ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC6489340 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Regulation of global gene expression in brain by TMP21.
Zhang Xiaojie X Wu Yili Y Cai Fang F Song Weihong W
Molecular brain 20190429 1
TMP21, a type I transmembrane protein of thep24 protein family, mediates protein trafficking and maturation. Dysregulation of TMP21 is implicated in the pathogenesis of Alzheimer's disease (AD). However, underlying mechanisms remain elusive. To reveal the function of TMP21 in the brain and the pathogenic role of TMP21 in the brain of AD, the global gene expression was profiled in the brain of TMP21 knockdown mice. We found that 8196 and 8195 genes are significantly altered in the hippocampus and ...[more]
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