Dataset Information

Effect of Diet Change on Gut Microbiota: Observational Pilot Study of Four Urban Couples.

ABSTRACT:

Background

Recent studies have focused on changes in gut microbiota following a dietary change. We identified how the distribution of gut microbiota changed when the dietary habits of young city dwellers improved using an intervention in which married couples shared the same dietary habits.

Methods

Four married couples in their 30s with irregular eating habits and sedentary lifestyles were asked whether they had any uncomfortable symptoms. A nutritionist advised them to reduce their intake of processed meats, carbonated beverages, and late-night snacks. After a 6-week intervention, subjects were asked whether they observed any changes in their symptoms. Their stool samples were collected before and after the intervention and analyzed to determine whether the gut microbiota had changed.

Results

After the dietary intervention, some subjective symptoms of the participants improved. Specifically, a subject who complained of frequent abdominal pain/diarrhea and one who complained of fatigue showed improvement in those symptoms. In addition, some subjects showed improvements in symptoms such as skin disease or constipation. Intestinal microorganisms between spouses who share the same dietary habits were found to be similar.

Conclusion

Improvements in eating habits can change the distribution of gut microbiota and alleviate various uncomfortable medical symptoms. Within married couples, the distribution of gut microbiota became similar when the spouses shared the same dietary habits. These results suggest a possible correlation between family-level changes in eating habits and the health of all family members.

SUBMITTER: Roh Y

PROVIDER: S-EPMC6489472 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Effect of Diet Change on Gut Microbiota: Observational Pilot Study of Four Urban Couples.

Roh Yujin Y Lee Jeongsang J Kim Won Gyoung WG Yi Gahye G Kim Byung Kwon BK Oh Bumjo B

Journal of obesity & metabolic syndrome 20171201 4

<h4>Background</h4>Recent studies have focused on changes in gut microbiota following a dietary change. We identified how the distribution of gut microbiota changed when the dietary habits of young city dwellers improved using an intervention in which married couples shared the same dietary habits.<h4>Methods</h4>Four married couples in their 30s with irregular eating habits and sedentary lifestyles were asked whether they had any uncomfortable symptoms. A nutritionist advised them to reduce the ...[more]

PMID: 31089528

Similar Datasets

Project description:BackgroundLow-energy diets (LEDs) comprise commercially formulated food products that provide between 800 and 1200 kcal/day (3.3-5 MJ/day) to aid body weight loss. Recent small-scale studies suggest that LEDs are associated with marked changes in the gut microbiota that may modify the effect of the LED on host metabolism and weight loss. We investigated how the gut microbiota changed during 8 weeks of total meal replacement LED and determined their associations with host response in a sub-analysis of 211 overweight adults with pre-diabetes participating in the large multicentre PREVIEW (PREVention of diabetes through lifestyle intervention and population studies In Europe and around the World) clinical trial.MethodsMicrobial community composition was analysed by Illumina sequencing of the hypervariable V3-V4 regions of the 16S ribosomal RNA (rRNA) gene. Butyrate production capacity was estimated by qPCR targeting the butyryl-CoA:acetate CoA-transferase gene. Bioinformatics and statistical analyses, such as comparison of alpha and beta diversity measures, correlative and differential abundances analysis, were undertaken on the 16S rRNA gene sequences of 211 paired (pre- and post-LED) samples as well as their integration with the clinical, biomedical and dietary datasets for predictive modelling.ResultsThe overall composition of the gut microbiota changed markedly and consistently from pre- to post-LED (P = 0.001), along with increased richness and diversity (both P < 0.001). Following the intervention, the relative abundance of several genera previously associated with metabolic improvements (e.g., Akkermansia and Christensenellaceae R-7 group) was significantly increased (P < 0.001), while flagellated Pseudobutyrivibrio, acetogenic Blautia and Bifidobacterium spp. were decreased (all P < 0.001). Butyrate production capacity was reduced (P < 0.001). The changes in microbiota composition and predicted functions were significantly associated with body weight loss (P < 0.05). Baseline gut microbiota features were able to explain ~25% of variation in total body fat change (post-pre-LED).ConclusionsThe gut microbiota and individual taxa were significantly influenced by the LED intervention and correlated with changes in total body fat and body weight in individuals with overweight and pre-diabetes. Despite inter-individual variation, the baseline gut microbiota was a strong predictor of total body fat change during the energy restriction period.Trial registrationThe PREVIEW trial was prospectively registered at ClinicalTrials.gov ( NCT01777893 ) on January 29, 2013.

Dataset Information

Effect of Diet Change on Gut Microbiota: Observational Pilot Study of Four Urban Couples.

Background

Methods

Results

Conclusion

Publications

Effect of Diet Change on Gut Microbiota: Observational Pilot Study of Four Urban Couples.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets