Ontology highlight
ABSTRACT:
SUBMITTER: Gautam S
PROVIDER: S-EPMC6489499 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Gautam Sanjivan S Fioravanti Jessica J Zhu Wei W Le Gall John B JB Brohawn Philip P Lacey Neal E NE Hu Jinhui J Hocker James D JD Hawk Nga Voong NV Kapoor Veena V Telford William G WG Gurusamy Devikala D Yu Zhiya Z Bhandoola Avinash A Xue Hai-Hui HH Roychoudhuri Rahul R Higgs Brandon W BW Restifo Nicholas P NP Bender Timothy P TP Ji Yun Y Gattinoni Luca L
Nature immunology 20190218 3
Stem cells are maintained by transcriptional programs that promote self-renewal and repress differentiation. Here, we found that the transcription factor c-Myb was essential for generating and maintaining stem cells in the CD8<sup>+</sup> T cell memory compartment. Following viral infection, CD8<sup>+</sup> T cells lacking Myb underwent terminal differentiation and generated fewer stem cell-like central memory cells than did Myb-sufficient T cells. c-Myb acted both as a transcriptional activator ...[more]