Ontology highlight
ABSTRACT:
SUBMITTER: Marcyk PT
PROVIDER: S-EPMC6489501 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20190115 6
The direct, catalytic substitution of unactivated alcohols remains an undeveloped area of organic synthesis. Moreover, catalytic activation of this difficult electrophile with predictable stereo-outcomes presents an even more formidable challenge. Described herein is a simple iron-based catalyst system which provides the mild, direct conversion of secondary and tertiary alcohols to sulfonamides. Starting from enantioenriched alcohols, the intramolecular variant proceeds with stereoinversion to p ...[more]