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Glomerular filtration rate: A prognostic marker in atrial fibrillation-A subanalysis of the AntiThrombotic Agents Atrial Fibrillation.


ABSTRACT: OBJECTIVE:An increased cardiovascular mortality and morbidity has been widely reported in patients with atrial fibrillation (AF). In this study, a subanalysis of the AntiThrombotic Agents Atrial Fibrillation (ATA-AF) is performed with the aim to evaluate estimated glomerular filtration rate (eGFR) as an independent prognostic marker of cardiovascular mortality and morbidity in patients with AF. METHODS AND RESULTS:The ATA-AF study enrolled 7148 patients with AF, in 360 Italian centers. The eGFR was calculated from data reported in patient notes or hospital database. This post-hoc analysis included 1097 AF patients with eGFR data available and 1-year clinical follow-up. The endpoint was assessed as cardiovascular mortality and/or hospital admission for cardiovascular causes at follow-up. Patients were also divided in two groups according to the eGFR (<60 and ?60?mL/min/1.73 m2 ). The Kaplan-Meyer curve for the mentioned endpoint showed a higher endpoint incidence in the group of patient with eGFR below 60?mL/min/1.73 m2 (P?

SUBMITTER: Proietti R 

PROVIDER: S-EPMC6489979 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Glomerular filtration rate: A prognostic marker in atrial fibrillation-A subanalysis of the AntiThrombotic Agents Atrial Fibrillation.

Proietti Riccardo R   Gonzini Lucio L   Pizzimenti Giovanni G   Ledda Antonietta A   Sanna Pietro P   AlTurki Ahmed A   Russo Vincenzo V   Lencioni Mauro M  

Clinical cardiology 20181204 12


<h4>Objective</h4>An increased cardiovascular mortality and morbidity has been widely reported in patients with atrial fibrillation (AF). In this study, a subanalysis of the AntiThrombotic Agents Atrial Fibrillation (ATA-AF) is performed with the aim to evaluate estimated glomerular filtration rate (eGFR) as an independent prognostic marker of cardiovascular mortality and morbidity in patients with AF.<h4>Methods and results</h4>The ATA-AF study enrolled 7148 patients with AF, in 360 Italian cen  ...[more]

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