Predictors of long-term mortality with cardiac resynchronization therapy in mild heart failure patients with left bundle branch block.

ABSTRACT: BACKGROUND:Cardiac resynchronization therapy (CRT) is highly beneficial in patients with heart failure (HF) and left bundle branch block (LBBB); however, up to 30% of patients in this selected group are nonresponders. HYPOTHESIS:We hypothesized that clinical and echocardiographic variables can be used to develop a simple mortality risk stratification score in CRT. METHODS:Best-subsets proportional-hazards regression analysis was used to develop a simple clinical risk score for all-cause mortality in 756 patients with LBBB allocated to the CRT with defibrillator (CRT-D) group enrolled in the multicenter automatic defibrillator implantation trial with cardiac resynchronization therapy. The score was used to assess the mortality risk within the CRT-D group and the associations with mortality reduction with CRT-D vs implantable cardioverter defibrillator (ICD) in each risk category. RESULTS:Four clinical variables comprised the risk score: age???65, creatinine ? 1.4 mg/dL, history of coronary artery bypass graft, and left ventricular ejection fraction (LVEF) < 26%. Every 1 point increase in the score was associated with 2-fold increased mortality within the CRT-D arm (P < 0.001). CRT-D was associated with mortality reduction as compared with ICD only in patients with moderate risk: score 0 (HR?= 0.80, P = 0.615), score 1 (HR?= 0.54, P = 0.019), score 2 (HR?= 0.54, P = 0.016), score 3-4 risk factors (HR?= 1.08, P = 0.811); however, the device by score interaction was not significant (P = 0.306). The score was also significantly predictive of left ventricular reverse remodeling (P < 0.001). CONCLUSIONS:Four clinical variables can be used for improved mortality risk stratification in mild HF patients with LBBB implanted with CRT-D.

SUBMITTER: Biton Y 

PROVIDER: S-EPMC6490024 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature