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Novel contaminants identified in fish kills in the Red River watershed, 2011-2013.


ABSTRACT: Provisional molecular weights and chemical formulas were assigned to 4 significant previously unidentified contaminants present during active fish kills in the Red River region of Oklahoma. The provisional identifications of these contaminants were determined using high-resolution liquid chromatography-time-of-flight mass spectrometry (LC-TOFMS), LC-Fourier transform ion cyclotron resonance mass spectrometry (LC-FTICRMS), and LC-ion trap mass spectrometry (LC-ITMS). Environmental water samples were extracted using a solid-phase extraction (SPE) method, and sediment samples were extracted using a modified sonication liquid extraction method. During screening of the samples, 2 major unknown chromatographic peaks were detected at m/z 624.3 and m/z 639.3. The peak at m/z 639.3 was firmly identified, through the use of an authentic standard, as a porphyrin, specifically chlorin-e6-trimethyl ester, with m/z 639.31735 (M?+?H)+ and molecular formula C37 H43 N4 O6 . The other major peak, at m/z 624.3 (M?+?H)+ , was identified as an amide-containing porphyrin. It was discovered that the amide compound was an artifact created during the SPE process by reaction of ammonium hydroxide at 1 of 3 potential reaction sites on chlorin-e6-trimethyl ester. Other unique nontargeted chemicals were also detected and the importance of their identification is discussed. Environ Toxicol Chem 2018;37:336-344. Published 2017 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America.

SUBMITTER: Jones-Lepp TL 

PROVIDER: S-EPMC6490966 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Novel contaminants identified in fish kills in the Red River watershed, 2011-2013.

Jones-Lepp Tammy L TL   Taguchi Vince V   Sovocool Wayne W   Betowski Don D   DeArmond Patrick P   Schumacher Brian B   Winnik Witold W   McMillin Rick R   Armstrong Chris C  

Environmental toxicology and chemistry 20171115 2


Provisional molecular weights and chemical formulas were assigned to 4 significant previously unidentified contaminants present during active fish kills in the Red River region of Oklahoma. The provisional identifications of these contaminants were determined using high-resolution liquid chromatography-time-of-flight mass spectrometry (LC-TOFMS), LC-Fourier transform ion cyclotron resonance mass spectrometry (LC-FTICRMS), and LC-ion trap mass spectrometry (LC-ITMS). Environmental water samples w  ...[more]

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