Unknown

Dataset Information

0

Unbiased Phenome-Wide Association Studies of Red Cell Distribution Width Identifies Key Associations with Pulmonary Hypertension.


ABSTRACT: Rationale: Red cell distribution width (RDW) is a prognostic factor in many diseases; however, its clinical utility remains limited because the relative value of RDW as a biomarker across disease states has not been established. Objectives: To establish an unbiased RDW disease hierarchy to guide the clinical use of RDW and to assess its relationship to cardiovascular hemodynamic and structural parameters. Methods: We performed phenome-wide association studies for RDW in discovery and replication cohorts derived from a deidentified electronic health record in nonanemic individuals. RDW values obtained within 30 days of echocardiogram or right heart catheterization were tested for association with structural and hemodynamic variables. Results: RDW was associated with 263 phenotypes in both men and women in the discovery cohort (n?=?121,530), 48 of which replicated in an independent cohort (n?=?2,039). The strongest associations were observed with pulmonary arterial hypertension (odds ratio [OR], 2.1; 95% confidence interval [CI], 1.9-2.3), chronic pulmonary heart disease (OR, 2.0; 95% CI, 1.9-2.2), and congestive heart failure (OR, 1.9; 95% CI, 1.8-2.0); P?-74 for all. By echocardiography, RDW was higher in the setting of right ventricular dysfunction than left ventricular dysfunction (P?P?-7) and remained strongly significant even when controlling for mean pulmonary capillary wedge pressure (21 vs. 29 mm Hg at 25th vs. 75th percentile RDW; P?-7). Conclusions: Among 1,364 coded medical conditions, increased RDW was strongly associated with pulmonary hypertension and heart failure. Hemodynamic and echocardiographic phenotyping confirmed these associations and underscored that the most clinically relevant phenotype associated with RDW was pulmonary hypertension. These hypothesis-generating findings highlight the potential shared pathophysiology of pulmonary hypertension and elevated RDW. Elevated RDW in the absence of anemia should alert clinicians to the potential for underlying cardiopulmonary disease.

SUBMITTER: Thayer TE 

PROVIDER: S-EPMC6491061 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

Unbiased Phenome-Wide Association Studies of Red Cell Distribution Width Identifies Key Associations with Pulmonary Hypertension.

Thayer Timothy E TE   Huang Shi S   Levinson Rebecca T RT   Farber-Eger Eric E   Assad Tufik R TR   Huston Jessica H JH   Mosley Jonathan D JD   Wells Quinn S QS   Brittain Evan L EL  

Annals of the American Thoracic Society 20190501 5


<b>Rationale:</b> Red cell distribution width (RDW) is a prognostic factor in many diseases; however, its clinical utility remains limited because the relative value of RDW as a biomarker across disease states has not been established. <b>Objectives:</b> To establish an unbiased RDW disease hierarchy to guide the clinical use of RDW and to assess its relationship to cardiovascular hemodynamic and structural parameters. <b>Methods:</b> We performed phenome-wide association studies for RDW in disc  ...[more]

Similar Datasets

| S-EPMC6461373 | biostudies-literature
| S-EPMC10426200 | biostudies-literature
| S-EPMC7220737 | biostudies-literature
| S-EPMC6415845 | biostudies-literature
| S-EPMC8008679 | biostudies-literature
| S-EPMC7391120 | biostudies-literature
| S-EPMC7677823 | biostudies-literature
| S-EPMC9932496 | biostudies-literature
| S-EPMC4368702 | biostudies-literature
| S-EPMC6200487 | biostudies-other