A Population-Based Twin Study of Childhood Irritability and Internalizing Syndromes.

ABSTRACT: Childhood irritability exhibits significant theoretical and empirical associations with depression and anxiety syndromes. The current study used the twin design to parse genetic and environmental contributions to these relationships. Children ages 9-14 from 374 twin pairs were assessed for irritability and symptoms of depression, generalized anxiety, panic, social phobia, and separation anxiety using dimensional self-report instruments. Multivariate structural equation modeling decomposed the correlations between these syndromes into genetic and environmental components to examine shared and specific risk domains. Irritability had significant associations with each internalizing symptom domain. Genetic contributions to irritability are moderately correlated with genetic risk for symptoms o

SUBMITTER: Rappaport LM 

PROVIDER: S-EPMC6491264 | biostudies-literature | 2020 Jul-Aug

REPOSITORIES: biostudies-literature