Dataset Information

Direction of TDCS current flow in human sensorimotor cortex influences behavioural learning.

ABSTRACT:

Background

Recent studies have shown that neurophysiological outcomes of transcranial direct current stimulation (TDCS) are influenced by current flow in brain regions between the electrodes, and in particular the orientation of current flow relative to the cortical surface.

Objective

We asked whether the directional effects of TDCS on physiological measures in the motor system would also be observed on motor behaviours.

Methods

We applied TDCS during the practice of a ballistic movement task to test whether it affected learning or the retention of learning 48?h later. TDCS electrodes were oriented perpendicular to the central sulcus and two current orientations were used (posterior-anterior, TDCS_PA; and anterior-posterior, TDCS_AP). Transcranial magnetic stimulation (TMS) was used to assess whether changes in corticospinal excitability reflected any behavioural changes.

Results

Directional TDCS_AP impaired the retention of learning on the ballistic movement task compared to TDCS_PA and a sham condition. Although TDCS_PA had no effect on learning or retention, it blocked the typical increase in corticospinal excitability after a period of motor practice.

Conclusions

Our results extend on previous reports of TDCS producing directionally specific changes in neurophysiological outcomes by showing that current direction through a cortical target also impacts upon behavioural outcomes. In addition, changes in corticospinal excitability after a period of motor practice are not causally linked to behavioural learning.

SUBMITTER: Hannah R

PROVIDER: S-EPMC6491497 | biostudies-literature | 2019 May - Jun

REPOSITORIES: biostudies-literature

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Publications

Direction of TDCS current flow in human sensorimotor cortex influences behavioural learning.

Hannah Ricci R Iacovou Anna A Rothwell John C JC

Brain stimulation 20190128 3

<h4>Background</h4>Recent studies have shown that neurophysiological outcomes of transcranial direct current stimulation (TDCS) are influenced by current flow in brain regions between the electrodes, and in particular the orientation of current flow relative to the cortical surface.<h4>Objective</h4>We asked whether the directional effects of TDCS on physiological measures in the motor system would also be observed on motor behaviours.<h4>Methods</h4>We applied TDCS during the practice of a ball ...[more]

PMID: 30738775

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Project description:The characteristic temporal relationship between actions and their sensory outcomes allows us to distinguish self- from externally generated sensory events. However, the complex sensory environment can cause transient delays between action and outcome calling for flexible recalibration of predicted sensorimotor timing. Since the neural underpinnings of this process are largely unknown this study investigated the involvement of the cerebellum by means of cerebellar transcranial direct current stimulation (ctDCS). While receiving anodal, cathodal, dual-hemisphere or sham ctDCS, in an adaptation phase, participants were exposed to constant delays of 150 ms between actively or passively generated button presses and visual sensory outcomes. Recalibration in the same (visual outcome) and in another sensory modality (auditory outcome) was assessed in a subsequent test phase during which variable delays between button press and visual or auditory outcome had to be detected. Results indicated that temporal recalibration occurred in audition after anodal ctDCS while it was absent in vision. As the adaptation modality was visual, effects in audition suggest that recalibration occurred on a supra-modal level. In active conditions, anodal ctDCS improved sensorimotor recalibration at the delay level closest to the adaptation delay, suggesting a precise cerebellar-dependent temporal recalibration mechanism. In passive conditions, the facilitation of inter-sensory recalibration by anodal ctDCS was overall stronger and tuned to larger delays. These findings point to a role of the cerebellum in supra-modal temporal recalibration across sensorimotor and perceptual domains, but the differential manifestation of the effect across delay levels in active and passive conditions points to differences in the underlying mechanisms depending on the availability of action-based predictions. Furthermore, these results suggest that anodal ctDCS can be a promising tool for facilitating effects of temporal recalibration in sensorimotor and inter-sensory contexts.

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Dataset Information

Direction of TDCS current flow in human sensorimotor cortex influences behavioural learning.

Background

Objective

Methods

Results

Conclusions

Publications

Direction of TDCS current flow in human sensorimotor cortex influences behavioural learning.

Similar Datasets

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