Post-synaptic Release of the Neuronal Tissue-Type Plasminogen Activator (tPA).
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ABSTRACT:
SUBMITTER: Lenoir S
PROVIDER: S-EPMC6491899 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Post-synaptic Release of the Neuronal Tissue-Type Plasminogen Activator (tPA).
Lenoir Sophie S Varangot Alexandre A Lebouvier Laurent L Galli Thierry T Hommet Yannick Y Vivien Denis D
Frontiers in cellular neuroscience 20190424
The neuronal serine protease tissue-type Plasminogen Activator (tPA) is an important player of the neuronal survival and of the synaptic plasticity. Thus, a better understanding the mechanisms regulating the neuronal trafficking of tPA is required to further understand how tPA can influence brain functions. Using confocal imaging including living cells and high-resolution cell imaging combined with an innovating labeling of tPA, we demonstrate that the neuronal tPA is contained in endosomal vesi ...[more]
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