Metabolically Active, Fully Hydrolysable Polymersomes.
Ontology highlight
ABSTRACT:
SUBMITTER: Zhu Y
PROVIDER: S-EPMC6492077 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Metabolically Active, Fully Hydrolysable Polymersomes.
Zhu Yunqing Y Poma Alessandro A Rizzello Loris L Gouveia Virginia M VM Ruiz-Perez Lorena L Battaglia Giuseppe G Williams Charlotte K CK
Angewandte Chemie (International ed. in English) 20190227 14
The synthesis and aqueous self-assembly of a new class of amphiphilic aliphatic polyesters are presented. These AB block polyesters comprise polycaprolactone (hydrophobe) and an alternating polyester from succinic acid and an ether-substituted epoxide (hydrophile). They self-assemble into biodegradable polymersomes capable of entering cells. Their degradation products are bioactive, giving rise to differentiated cellular responses inducing stromal cell proliferation and macrophage apoptosis. Bot ...[more]
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